Kidney: two organs located on either side of the spine, above the waist. We think of them as being in our “back”. Their function is to clean the body of waste materials and maintain a balance of fluids by the making of urine.
Kidney Disease: is diagnosed when the kidney organs in the body lose their normal function. If they stop working altogether, kidney failure is diagnosed.
Adynamic Bone Disease (ABD): is the name of the condition that develops in kidney failure situations and in bone disease patients, where the bones slow or stop their normal building up and breaking down process. It is sometimes referred to as “Low Bone Turnover”.
Secondary Condition: is a health problem or condition which develops because of another condition. An example would be: Renal Failure (kidney failure) often results in hyperparathyroidisma secondary condition, where the parathyroid hormone is being produced in excess by the thyroid gland, resulting in excess calcium in the body and not enough phosphorus, with both being excreted in larger amounts in the urine. The body’s calcium balancing mechanism (metabolism) is out of balance.
Parathyroid Glands: (see diagrams above) Four tiny glands which are inside the thyroid gland (see below) which produce parathyroid hormone that regulates calcium within the body.
Thyroid Gland: a gland which is located in front of the neck’s spinal vertebrae, and produces thyroid hormone for the body. This gland is home to the parathyroid glands defined above.
Bone Biopsy: A surgical procedure which involves the insertion of a special needle to withdraw a sample of bone (usually taken from the Iliac crest, or top of the large hip bones within the pelvis) from patients who need to have the density and condition of their bones analyzed. The sample is then analyzed to determine the patient’s bone status. This is considered the “gold standard” in diagnosis of bone conditions.
Iliac Crest: The larger, curved surface of the top of the pelvic bones, from which bone biopsies are frequently taken.
Calcified: Hardened by excess amounts of calcium - often to the point of destroying the function of the organ or tissue itself.
PTH Accuratio™ -- 1-84 PTH/7-84 PTH ratio: The new type of PTH testing offered by Scantibodies Clinical Laboratory, which provides all of the values the physician needs to determine bone status and the presence of adynamic bone disease. This includes a Total (intact) PTH value, a 1-84 PTH Whole CAP Assay value, and the 1/84 PTH/7-84 PTH ratiowhich is the determining factor.
For a complete dictionary for dialysis and transplant patients, go on-line at the following address: www.esrdnetwork6.org, or request by email at firstname.lastname@example.org, or call the Southeastern Kidney Council, Inc. at 1-800-524-7139 for the book: ESRD from A to Z A dictionary for dialysis and transplant patients. (A glossary of terms often used when talking about dialysis, transplantation and End-Stage Renal Disease.)