7-84 PTH circulates in the blood of normals and patients with a range of 10:1 to 1:10 compared to 1-84 PTH. (J Bone Miner Res 2001; 16(4):605-614).
7-84 PTH is produced in the parathyroid gland. (Kidney Int 2000; 58:753-761, J Bone Miner Res 2001(Sept); 16:(Suppl 1)S156 & J Clin Endocrinol Metab 2003; 88(10):4725-4730).
7-84 PTH has a half life that is twice as long as 1-84 PTH. (Eur J Endocrinol 2003; 149:301-306 & Surgery 2004(Feb); 135:149-156).
7-84 PTH is hypocalcemic. (Kidney Int 2000; 58:753-761).
7-84 PTH down regulates the 1-84 PTH type 1 receptor. (J Bio Chem 2003(Oct); 278(44):43787-43796).
7-84 PTH binds to bone cells. (Endocrinol 2003; 144(4):1135-1138).
7-84 PTH inhibits osteoblast and osteoclast formation. (Endocrinol 2003; 144(4):1135-1138).
7-84 PTH inhibits bone resorption. (Endocrinol 2002; 143(1):171-176).
7-84 PTH operates through its own C-terminal PTH receptor. (Endocrinol 2002;143(1):171-176).
7-84 PTH lowers bone turnover and can cause adynamic bone disease. (Endocrinol 2003; 144(4):1135-1138).
7-84 PTH inhibits the secretion of 1-84 PTH. (J Am Soc Nephrol 2004(Oct); 15(10):F-PO1002, 284A).
7-84 PTH blood levels are regulated by calcium (and vitamin D). (Kidney Int 2001; 60:1460-1468).
7-84 PTH increases more rapidly than 1-84 PTH with decreasing kidney function. (Pediatric Nephrology 2004: Dec 31 online, 10.1007/s00467-004-1735-2; Am J Kidney Dis 2004; 43(4):29, A22; J Am Soc Nephrol(2003); 14:SU-PO693,686A.
7-84 PTH compared to 1-84 PTH predicts bone turnover in ESRD. (Kidney Int 2001; 60:1460-1468).
7-84 PTH increases are associated with growth retardation in pediatric ESRD patients. (J Am Soc Nephrol 2003(Nov); 14:SU-PO694, 687A).